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Cisco AnyConnect “Failed to initialize connection subsystem”

  • 1. Close the Cisco AnyConnect Window and the taskbar mini-icon
  • 2. Right click vpnui.exe in the “Cisco AnyConnect Secure Mobility Client” folder. (I have it in “C:\Program Files (x86)\Cisco\Cisco AnyConnect Secure Mobility Client\”
  • 3. Click on the “Run compatibility troubleshooter” button
  • 4. Choose “Try recommended settings”.
  • 5. The wizard suggests Windows 8 compatibility.
  • 6. Click “Test Program”.  This will open the program.
  • 7. Close
  • Some people may need to repeat the above steps for vpnagent.exe. That is the local service that supports the client user interface.